Fine structure of synapses on dendritic spines
نویسندگان
چکیده
منابع مشابه
Fine structure of synapses on dendritic spines
Camillo Golgi's "Reazione Nera" led to the discovery of dendritic spines, small appendages originating from dendritic shafts. With the advent of electron microscopy (EM) they were identified as sites of synaptic contact. Later it was found that changes in synaptic strength were associated with changes in the shape of dendritic spines. While live-cell imaging was advantageous in monitoring the t...
متن کاملPathology of Synapses and Dendritic Spines
1Centro de Bioloǵıa Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Cient́ıficas (CSIC) and Universidad Autónoma de Madrid, Nicolás Cabrera, 28049 Madrid, Spain 2Experimental Dementia Research Unit, Wallenberg Neuroscience Center and Department of Experimental Medical Science, Lund University, Sölvegatan 19, 221 84 Lund, Sweden 3Department of Anatomy and Neurobiology, Central South...
متن کاملSynapses and Dendritic Spines as Pathogenic Targets in Alzheimer's Disease
Synapses are sites of cell-cell contacts that transmit electrical or chemical signals in the brain. Dendritic spines are protrusions on dendritic shaft where excitatory synapses are located. Synapses and dendritic spines are dynamic structures whose plasticity is thought to underlie learning and memory. No wonder neurobiologists are intensively studying mechanisms governing the structural and f...
متن کاملStructure and function of dendritic spines.
Spines are neuronal protrusions, each of which receives input typically from one excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling systems essential for synaptic function and plasticity. Numerous brain disorders are associated with abnormal dendritic spines. Spine formation, plasticity, and maintenance depend on synaptic activity and can be modulated by sens...
متن کاملStructure, development, and plasticity of dendritic spines.
Dendritic spines are distinguished by their shapes, subcellular composition, and synaptic receptor subtypes. Recent studies show that actin-dependent movements take place in spine heads, that spines emerge from stubby and shaft synapses after dendritic filopodia disappear, and that spines can form without synaptic activation, are maintained by optimal activation, and are lost with excessive act...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Neuroanatomy
سال: 2014
ISSN: 1662-5129
DOI: 10.3389/fnana.2014.00094